If you ever feel like riffing a video game again, try this one, a cult classic for the GameCube from Goichi Suda, aka Suda51, aka a guy who alienates gamers by throwing them curveballs left and right until they're not sure whether the game is mad genius or pretentious crap.

The plot of killer7 involves...um....well, there's stuff that happens, I can say that for certain. It's like a fever dream you might have after watching a Tarantino movie marathon. The titular killer7 are assassins hired by the American government to track down and kill Kun Lan, leader of a cult called Heaven Smile. The cult members are turned into invisible humanoid monsters who can only laugh and kill people by grabbing them and exploding.

If that doesn't sound weird enough...

-The assassins you control include a blind teenager who reloads his guns by kicking the magazines into place, a shirtless mute who throws knives and can turn invisible, a luchadore with grenade launchers and a barefoot woman who reveals secret passages by slitting her wrist and letting the high-pressure blood spray everywhere. And they're all the multiple personalities of an old man in a wheelchair that he can somehow manifest in the real world.

-Throughout the levels, you run into ghosts of people the assassins have killed before, who give you cryptic advice in heavily distorted voices. (This was done because the Japanese VAs for the ghosts read their lines in butchered English and they didn't bother to hire new actors for the western release.) The ghosts include a guy in a gimp suit suspended from a wire, a thug in a sleeveless shirt that has a different message on it every time you see him, the severed head of a crazy teen girl, and the boss you killed on the previous level.

-The plot, such as it is, includes such WTF elements as international politics being determined with a game of mahjong, a band of murderous Power Ranger knockoffs brought to life by a comic book artist, a cult leader who is immune to all diseases and feeds his blood to his followers, and a grade school in Seattle that controls the outcome of every presidential election.

Supergreatfriend has uploaded a full playthrough of the game in which he makes a valiant attempt to explain what the Amy Heckerling is going on.
https://www.youtube.com/playlist?list=PLaSPgE4K0SB20ZicuxRFLpHONXWmTXTtK