The film is about an all-female motorcycle gang named the 'Cycle Sluts', who cruise into the isolated town of Zariah looking for a good time. Here, an evil scientist-turned-mortician has been killing local townspeople with the aid of his long-suffering dwarf assistant ("If God wanted you to do normal things, he would have made you look like normal people") and turning them into zombies to use as labor at an abandoned mine. The mine is too radioactive after underground nuclear testing to be mined by living people. Although the scientist later admits that the real reason he's been doing it is not the money, but because he's just plain mean.