Definitely wouldn't be easy for them to tackle an FMV (full motion) video game without cheating with an entire game walkthrough (so that should be how they would record the video before overlaying the commentary track.

But that shouldn't stop them from experimenting on these out of the box style riffing treatments with differing forms of media.

https://www.imdb.com/title/tt0164974/reference
https://www.youtube.com/watch?v=YP41bEhCEIE